top of page
Laboratory

Past projects

DISCOVER

This Horizon 2020-funded MSCA-RISE project DISCOVER, running from 01.01.2018 to 31.12.2022, formed the basis of the TRAIL-4-Life consortium.

 

• Dr. Eva Szegezdi (Project Coordinator): National University of Ireland (NUI, Galway, Ireland)

• Dr. Leif A. Eriksson: Cell Stress Discoveries, Ltd. (Galway, Ireland)

• Dr. Matthieu LeGallo: University of Rennes (France)

• Dr. Philippe Krebs: University Bern (Bern, Switzerland)

• Dr. Olivier Micheau: Institut National de la Sante et de la Recherache Medicale (Dijon, France)

• Dr. Aristotelis Chatziioannou: eNIOS Applications (Athens, Greece)

• Dr. Duygu Sag: Izmir Biomedicine and Genome Center (IBG; Izmir, Turkey)

• Dr. Gerhard Wingender: Izmir Biomedicine and Genome Center (IBG; Izmir, Turkey)

Petri Dishes_edited.jpg

DISCOVER achievements:

​

  • We set up our in silico pipeline to develop small molecule inhibitors (SMIs) for the non-canonical DR-signalling pathway and produced a first a-cFLIP SMI-candidate.

​

  • We developed essential tools to study the protein-protein interaction of the non-canonical DR-signalling pathway and demonstrated the feasibility of our proximity-labelling approach.

​

  • We made major discoveries on the role of the non-canonical DR-signalling pathway in immune cells (NK cells, macrophages, iNKT cells).

For inquiries or additional information about DISCOVER, please contact Dr. Szegezdi (<eva.szegezdi@universityofgalway.ie>).

This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No. 101130240. This communication material reflects only the authors’ view and the Research Executive Agency or the European Commission are not responsible for any use that may be made of the information it contains.

Project acronym and title: DISCOVER - Death receptor signalling in tumour immune editing

Call name: H2020-MSCA-RISE-2017

Project number: 777995

Project Coordinator: Dr. Eva Szegezdi (University of Galway; Galway, Ireland)

Project period: 01.01.2018 – 31.12.2022

Cordis link: https://cordis.europa.eu/project/id/777995

bottom of page